El Cazador de la Bruja (The Hunter of the Witch)

El Cazador de la Bruja (The Hunter of the Witch) is a 2007 anime series about a bounty hunter, Nadie, who teams up with a mysterious, amnesiac girl named Ellis, who is wanted for murder. The two travel south through Mexico to uncover the truth about Ellis's past, guided by a mysterious stone and a destination called the "Eternal City," all while being pursued by an underground society of "Hunters". The series is known for its "girls with guns" theme, modern Western setting, and the developing bond between the two protagonists.